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Afaf E. Osman
( out of 31 reviews )

Afaf E. Osman, MD

Languages spoken: Arabic, English

  • Dr. Afaf E. Osman is an Assistant Professor specializing in Hematology and Hematologic Malignancies within the Division of Hematology at the University of Utah. Board certified in Hematology and Medical Oncology, Dr. Osman focuses on the diagnosis, management, and underlying mechanisms of clonal hematopoiesis, myeloid malignancies, and bone marrow failure syndromes.

    After completing her Internal Medicine residency at Johns Hopkins University and Hematology and Oncology fellowship at the University of Chicago, Dr. Osman joined the faculty at the University of Utah in 2020. She is actively involved in multi-institutional studies and clinical trials aimed at improving the understanding and treatment of conditions such as acute myeloid leukemia (AML) and clonal cytopenias of undetermined significance (CCUS).

    Dr. Osman's research centers on uncovering the genetic and inflammatory drivers of myeloid malignancies, with a focus on how these factors contribute to disease progression and therapeutic resistance. Her work emphasizes the translation of laboratory findings into clinical strategies to enhance patient outcomes. Dr. Osman is a member of American Society of Hematology, Society of Hematologic Oncology, and American Society of Clinical Oncology.

    Board Certification

    American Board of Internal Medicine (Internal Medicine)
    American Board of Internal Medicine (Sub: Hematology)
    American Board of Internal Medicine (Sub: Medical Oncology)

    Patient Rating

    4.9 /5
    ( out of 31 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety.
    Patients are de-identified for confidentiality and patient privacy.

    October 29, 2024
    HUNTSMAN CANCER CENTER

    Exelent and very professional

    September 12, 2024
    HUNTSMAN CANCER CENTER

    I'm very pleased to have Dr. Osman as my Dr.

    July 07, 2024
    HUNTSMAN CANCER CENTER

    Dr. Osman seems to be very thorough and I can tell that she cares about my health.

    June 17, 2024
    HUNTSMAN CANCER CENTER

    Dr Osman understands and listens to my issues.Excellent and concerned Dr

    June 16, 2024
    HUNTSMAN CANCER CENTER

    Very caring doctor that listens to her patients. Makes decisions based on facts.

    May 27, 2024
    HUNTSMAN CANCER CENTER

    Dr. Osman is thorough and works very hard at figuring out how to treat my disease/disorder. I like how she sits down and discusses labs/test results; and draws out treatment options on paper. She is personable and caring. Plus she has a wonderful team supporting her.

    May 17, 2024
    HUNTSMAN CANCER CENTER

    Dr. Osman is very thoughtful and caring. She sits down with me to explain labs, tests, treatment plan and options. I'm grateful she is guiding me through this journey!

    April 29, 2024
    HUNTSMAN CANCER CENTER

    Very Professional yet Very Personable - Everything you want in a Doctor

    March 24, 2024
    HUNTSMAN CANCER CENTER

    Dr. Osman explains everything clearly and takes the time to explain if you don't understand.

    See More Patient Comments

  • Dr. Afaf E. Osman is an Assistant Professor specializing in Hematology and Hematologic Malignancies within the Division of Hematology at the University of Utah. Board certified in Hematology and Medical Oncology, Dr. Osman focuses on the diagnosis, management, and underlying mechanisms of clonal hematopoiesis, myeloid malignancies, and bone marrow failure syndromes.

    After completing her Internal Medicine residency at Johns Hopkins University and Hematology and Oncology fellowship at the University of Chicago, Dr. Osman joined the faculty at the University of Utah in 2020. She is actively involved in multi-institutional studies and clinical trials aimed at improving the understanding and treatment of conditions such as acute myeloid leukemia (AML) and clonal cytopenias of undetermined significance (CCUS).

    Dr. Osman's research centers on uncovering the genetic and inflammatory drivers of myeloid malignancies, with a focus on how these factors contribute to disease progression and therapeutic resistance. Her work emphasizes the translation of laboratory findings into clinical strategies to enhance patient outcomes. Dr. Osman is a member of American Society of Hematology, Society of Hematologic Oncology, and American Society of Clinical Oncology.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Primary
    Academic Divisions Hematology & Hematologic Malignancies
    Board Certification
    American Board of Internal Medicine (Internal Medicine)
    American Board of Internal Medicine (Sub: Hematology)
    American Board of Internal Medicine (Sub: Medical Oncology)

    Education history

    Fellowship Leukemia - University of Chicago Research Fellow
    Fellowship Hematology & Oncology - University of Chicago Clinical Fellow
    Residency Internal Medicine - Johns Hopkins Hospital Resident
    Doctoral Training Medicine - Weill Cornell Medical College in Qatar M.D.
    Certification Premedical Program - Weill Cornell Medical College in Qatar Pre Med

    Selected Publications

    Journal Article

    1. Dravillas CE, Coleman SS 4th, Hoyd R, Caryotakis G, Denko L, Chan CHF, Churchman ML, Denko N, Dodd RD, Eljilany I, Hardikar S, Husain M, Ikeguchi AP, Jin N, Ma Q, McCarter MD, Osman AEG, Robinson LA, Singer EA, Tinoco G, Ulrich CM, Zakharia Y, Spakowicz D, Tarhini AA, Tan AC, exORIEN Consortium (2023). The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors. Cancer Res Commun, 4(8), 1978-1990. ()
    2. Xie Z, Komrokji RS, Al-Ali N, Regelson A, Geyer S, Patel AA, Saygin C, Zeidan AM, Bewersdorf JP, Mendez LM, Kishtagari A, Zeidner JF, Coombs CC, Madanat YF, Chung SS, Badar T, Foran JM, Desai P, Tsai C, Griffiths EA, Al Malki MM, Amanam I, Lai C, Deeg HJ, Ades L, Arana-Yi C, Osman AE, Dinner SN, Abaza Y, Taylor J, Chandhok NS, Soong D, Brunner AM, Carraway HE, Singh A, Elena C, Ferrari J, Galli A, Pozzi S, Padron E, Patnaik MM, Malcovati L, Savona MR, Al-Kali A (2024). Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence. Blood. ()
    3. Benej M, Hoyd R, Kreamer M, Wheeler CE, Grencewicz DJ, Choueiry F, Chan CHF, Zakharia Y, Ma Q, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Robinson LA, Singer EA, Ikeguchi AP, McCarter MD, Tinoco G, Husain M, Jin N, Tan AC, Osman AEG, Eljilany I, Riedlinger G, Schneider BP, Benejova K, Kery M, Papandreou I, Zhu J, Denko N, Spakowicz D, exORIEN Consortium (2023). The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer. Cancer Res Commun, 4(7), 1690-1701. ()
    4. Osman AEG, Rets A, Patel AB (2024). KRAS mutations, autoimmunity and female sex in chronic myelomonocytic leukemia. Leuk Res, 138, 107466. ()
    5. Wang C, Ma A, Li Y, McNutt ME, Zhang S, Zhu J, Hoyd R, Wheeler CE, Robinson LA, Chan CHF, Zakharia Y, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Singer EA, Ikeguchi AP, McCarter MD, Denko N, Tinoco G, Husain M, Jin N, Osman AEG, Eljilany I, Tan AC, Coleman SS, Denko L, Riedlinger G, Schneider BP, Spakowicz D, Ma Q, exORIEN Consortium (2023). A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset. Cancer Res Commun, 4(2), 293-302. ()
    6. Wheeler CE, Coleman SS 4th, Hoyd R, Denko L, Chan CHF, Churchman ML, Denko N, Dodd RD, Eljilany I, Hardikar S, Husain M, Ikeguchi AP, Jin N, Ma Q, McCarter MD, Osman AEG, Robinson LA, Singer EA, Tinoco G, Ulrich CM, Zakharia Y, Spakowicz D, Tarhini AA, Tan AC (2023). The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors. ()
    7. Wang C, Ma A, McNutt ME, Hoyd R, Wheeler CE, Robinson LA, Chan CHF, Zakharia Y, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Singer EA, Ikeguchi AP, McCarter MD, Denko N, Tinoco G, Husain M, Jin N, Osman AEG, Eljilany I, Tan AC, Coleman SS 4th, Denko L, Riedlinger G, Schneider BP, Spakowicz D, Ma Q (2023). A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset. ()
    8. Osman AEG, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai M, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LA (2022). Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv, 7(9), 1910-1914. ()
    9. Osman A, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai MJ, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LA (2022). Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv, 7(9), 1910-1914. ()
    10. Yu B, Osman AEG, Sladojevic N, Prabhu N, Tai HC, Chen D, Perla G, Park L, Larson RA, Liao JK (2022). Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity. JACC CardioOncol, 4(3), 371-383. ()
    11. Croci DM, Gamboa NT, Osman AEG, Maese L, Mazur M, Bisson EF, Dailey AT (2021). Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration. Clin Neurol Neurosurg, 212, 107064. ()
    12. Feusier JE, Madsen MJ, Avery BJ, Williams JA, Stephens DM, Hu B, Osman AEG, Glenn MJ, Camp NJ (2021). Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk. J Transl Genet Genom, 5, 189-199. ()
    13. Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, DePersia AHW, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME and Churpek JE (2020). Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Adv, 4(19), 4873-4886.
    14. Osman A, Gocke CD, Gladstone DE (2016). Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones. Clin Lymphoma Myeloma Leuk, 17(2), 97-99. ()
    15. Osman A, et al (2014). Sudden Worsening of DRESS Syndrome on Tapering Steroid Dose with Dramatic Improvement on N-acetylcysteine and Steroid Dose Escalation. 6(2), 101-10.

    Review

    1. Liu J, Osman AEG, Bolton K, Godley LA (2023). Germline predisposition to clonal hematopoiesis. [Review]. Leuk Res, 132, 107344. ()
    2. Croci DM, Gamboa NT, Osman AEG, Maese L, Mazur M, Bisson EF, Dailey AT (2021). Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration. [Review]. Clin Neurol Neurosurg, 212, 107064. ()
    3. Osman AEWG (2021). When are idiopathic and clonal cytopenias of unknown significance (ICUS or CCUS)? [Review]. Hematology Am Soc Hematol Educ Program, 2021(1), 399-404. ()
    4. Osman AEG, Deininger MW (2021). Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions. [Review]. Blood Rev, 49, 100825. ()
    5. Osman A, Patel JL (2021). Diagnostic Challenge and Clinical Dilemma: The Long Reach of Clonal Hematopoiesis. [Review]. Clin Chem, 67(8), 1062-1070. ()
    6. Osman AEG, Luke JJ (2019). The Impact of the Fecal Microbiome on Cancer Immunotherapy. [Review]. BioDrugs, 33(1), 1-7. ()
    7. Akpan IJ, Osman AEG, Drazer MW, Godley LA (2018). Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies. [Review]. Curr Hematol Malig Rep, 13(6), 426-434. ()
    8. Osman AEG, Anderson J, Churpek JE, Christ TN, Curran E, Godley LA, Liu H, Thirman MJ, Odenike T, Stock W, Larson RA (2018). Treatment of Acute Promyelocytic Leukemia in Adults. [Review]. J Oncol Pract, 14(11), 649-657. ()

    Case Report

    1. Osman A, Galiatsatos P, Bose S, Danoff S (2017). Rheumatoid arthritis causing diffuse alveolar haemorrhage: a novel therapeutic approach. BMJ Case Rep, 2017. ()

    Abstract

    1. Osman AYu B, Glavin N, Polonsky T, Liao J, Larson RA (2018). ABL Tyrosine Kinase Inhibitors (TKIs) are Associated with Increased Rho-Associated Kinase (ROCK) Activity that May Contribute to Vascular Toxicity in Patients with Chronic Myeloid Leukemia (CML). Poster session: 632 Chronic Myeloid Leukemia: Therapy, American Society of Hematology 60th Annual Meeting, San Diego, CA [Abstract]. 132(Suppl 1), 1739.
    2. Osman AGaliatsatos PBose S (2017). Diffuse Alveolar Hemorrhage as a Rare Manifestation of Rheumatoid Arthritis. Poster session presented at the Autoimmune Lung Disease: Case Reports Thematic Poster Session. American Thoracic Society International Conference, Washington, DC [Abstract]. 195, A1460.

    Other

    1. Osman AEG, Luke JJ (2019). The Gut Microbiome and Cancer Immunotherapy. (4(8), pp. 14, 15).