91麻豆天美直播

Changhong Xing
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Changhong Xing, MD, PhD

Languages spoken: English

Clinical Locations

ARUP

Salt Lake City
801-581-2121

Craig H. Neilsen Rehabilitation Hospital

Salt Lake City
801-646-8000

University of Utah Hospital

Pathology
Salt Lake City
801-581-2121

  • Specialties

    • Pathology, Anatomical

    Board Certification

    American Board of Pathology (Sub: Anatomic Path)

  • Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Fellowship Neuropathology - University of Texas Southwestern Medical Center Fellow
    Residency Pathology - University of Texas Southwestern Medical Center Resident
    Research Fellow Massachusetts General Hospital Harvard Medical School Research Fellow
    Doctoral Training Neurobiology - Tsinghua University Ph.D.
    Professional Medical Pathology - Peking University Health Science Center MMed
    Undergraduate Medicine - Hebei Medical University BMed

    Selected Publications

    Journal Article

    1. Li W, Mandeville ET, Durn-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Tanaka M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger BJ, Moro MA, Lo EH (2022). Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun, 13(1), 7812. ()
    2. Yu F, Saand A, Xing C, Lee JW, Hsu L, Palmer OP, Jackson V, Tang L, Ning M, Du R, Kochanek PM, Lo EH, Chou SH (2021). CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. J Cereb Blood Flow Metab, 41(10), 2524-2533. ()
    3. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C (2020). Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab, 40(1_suppl), S34-S48. ()
    4. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J (2020). Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology, 94(12), e1281-e1293. ()
    5. Deng W, Xing C, David R, Mastroeni D, Ning M, Lo EH, Coleman PD (2019). AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging Dis, 10(6), 1146-1158. ()
    6. Du Y, Li W, Lin L, Lo EH, Xing C (2019). Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One, 14(7), e0218965. ()
    7. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH (2018). Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis, 126, 117-123. ()
    8. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X (2018). HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPAR纬 activity in聽vitro. J Neurochem, 149(2), 298-310. ()
    9. Guo S, Tjrnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH (2018). Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab, 38(12), 2236-2250. ()
    10. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y (2018). L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res, 34(3), 477-488. ()
    11. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res, 135, 201-211. ()
    12. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH (2018). Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem, 146(2), 160-172. ()
    13. Xing C, Li W, Deng W, Ning M, Lo EH (2018). A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation, 15(1), 143. ()
    14. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets, 17(5), 338-347. ()
    15. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X (2017). Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci, 14(10), 927-936. ()
    16. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K (2017). A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev, 26(14), 1078-1085. ()
    17. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y (2017). Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B, 7(4), 470-478. ()
    18. Lin L, Desai R, Wang X, Lo EH, Xing C (2017). Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation, 14(1), 101. ()
    19. Xing C, Lo EH (2016). Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol, 152, 181-199. ()
    20. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C (2016). Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab, 37(4), 1425-1434. ()
    21. Xing C, Hayakawa K, Lo EH (2016). Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res, 8(1), 1-2. ()
    22. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH (2016). Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med, 22(11), 1335-1341. ()
    23. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH (2016). Transfer of mitochondria from astrocytes to neurons after stroke. Nature, 535(7613), 551-5. ()
    24. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH (2016). Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma, 33(14), 1303-16. ()
    25. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS (2015). Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem, 136(4), 851-858. ()
    26. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X (2015). Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res, 6(6), 478-84. ()
    27. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY (2014). Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther, 21(4), 304-8. ()
    28. Wu L, Du Y, Lok J, Lo EH, Xing C (2015). Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem, 132(6), 622-8. ()
    29. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH (2014). Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke, 45(7), 2085-92. ()
    30. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH (2014). Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol, 1135, 393-402. ()
    31. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH (2013). Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest, 123(8), 3373-7. ()
    32. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K (2012). Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets, 12(3), 302-15. ()
    33. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K (2012). Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J, 27(2), 437-45. ()
    34. Xing C, Arai K, Lo EH, Hommel M (2012). Pathophysiologic cascades in ischemic stroke. Int J Stroke, 7(5), 378-85. ()
    35. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X (2012). Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci, 13, 67. ()
    36. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH (2012). Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab, 32(6), 983-8. ()
    37. Xing C, Hayakawa K, Lok J, Arai K, Lo EH (2012). Injury and repair in the neurovascular unit. Neurol Res, 34(4), 325-30. ()
    38. Liu N, Yu Z, Xiang S, Zhao S, Tjrnlund-Wolf A, Xing C, Zhang J, Wang X (2012). Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J, 443(1), 153-64. ()
    39. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH (2012). The vasculome of the mouse brain. PLoS One, 7(12), e52665. ()
    40. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH (2011). Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol, 26(9), 1193-8. ()
    41. Xing C, Arai K, Park KP, Lo EH (2010). Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res, 35(7), 1092-7. ()
    42. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X (2009). L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol, 621(1-3), 38-45. ()
    43. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X (2009). Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience, 162(2), 396-403. ()
    44. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH (2009). Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res, 87(11), 2571-7. ()
    45. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836-42. ()
    46. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH (2009). CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol, 217(1), 165-70. ()
    47. Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL (2008). Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res, 31(1), 43-51. ()
    48. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X (2008). Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res, 87(1), 164-70. ()
    49. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH (2008). Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem, 108(2), 430-6. ()
    50. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X (2008). l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett, 434(2), 224-9. ()
    51. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007). Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol, 205(1), 222-9. ()
    52. Xing C, Yin Y, He X, Xie Z (2006). Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res, 1072(1), 30-5. ()
    53. Xing C, Peng Y, Chang R, Yin Y, Xie Z (2005). Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells. Cell Biol Int, 29(9), 803-8. ()
    54. Xing C, Yin Y, Chang R, He X, Xie Z (2005). A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett, 384(1-2), 93-7. ()
    55. Gong H, Shen P, Jin L, Xing C, Tang F (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm, 20(2), 155-62. ()
    56. Hai-Yang G, Ping S, Li JI, Chang-Hong X, Fu T (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. J Exp Ther Oncol, 4(3), 181-7. ()
    57. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y (2002). [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi, 82(7), 481-3. ()
    58. Xing C, Gong E (1998). Detection of hepatitis C virus RNA in liver tissues by in situ hybridization. Cell Vis, 5(1), 80-2. ()