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Fighting Adrenal Cancer through Less Toxic Treatments

Read Time: 3 minutes


Cancer Researcher at Huntsman Cancer Institute
Assistant Professor of Oncological Sciences at the University of Utah

Katie Basham, PhD
Katie Basham, PhD

鈥淢y 5 is for my mom. She鈥檚 the person who really inspired my career path. And she鈥檚 the person who, growing up, always taught me that I could go on and do anything that I wanted, which I think is a really powerful message to hear as a kid. And science is definitely a difficult career path, so for me that鈥檚 been kind of the light that helps push through all the challenges, knowing that, one, I can do it because she always told me that I could and, two, that it will help people like her.鈥
鈥擪atie Basham

As a freshman in high school, Katie Basham received some news that would change her life鈥攈er mother was diagnosed with multiple myeloma.

鈥淭hat was a scary time because I was 15 and I didn鈥檛 know what cancer was,鈥 Basham says. 鈥淚 started to learn through her experience and that inspired me to want to help cancer patients everywhere.鈥

Basham headed down the only path she knew to make a difference for cancer patients, which was becoming a doctor. But Basham soon became intrigued by another path that would allow her to pursue her passion to focus on developing better treatments for cancer. She transitioned her training to pursue laboratory science, where she would have the opportunity to explore why some treatments don鈥檛 work and why some treatments produce benefits but have difficult side effects.

鈥淚 just found that cycle really frustrating. And the problem is that there just isn鈥檛 enough known to create better therapies,鈥 Basham says.

Unfortunately, she lost her mom to cancer during her last year of college.

鈥淚 relate very strongly to patients and their families, and I really enjoy this [research] path because there鈥檚 so much intellectual freedom and so much ability to work on questions that you鈥檙e passionate about,鈥 says Basham.

Basham took a leap of faith and started her work in cancer research at Huntsman Cancer Institute (HCI) and the University of Utah. For five years, she worked in the lab of , studying breast cancer research. She then headed to the University of Michigan, where she stayed for six years.

The 5 For The Fight Fellowship, a grant for three years, is a 鈥渨elcome home鈥 present of sorts. She receives the fellowship as she returns to HCI to set up her own laboratory studying adrenal cancers. Currently there is a single, often toxic, therapy for the disease.

鈥淢ost patients have a really difficult time tolerating the drug,鈥 Basham says. 鈥淢y research is really aimed at trying to understand adrenal cancer and the different genes and pathways that are altered, and then trying to create new therapies that are more targeted鈥攐nes that are going to kill the cancer cells but not harm normal cells.鈥

When she got word she received the 5 For The Fight fellowship, she was thrilled to know that she had both the financial and moral support of the community in Utah.

鈥淚t really is huge for starting out in my career, starting my laboratory, which is a big step in my professional career. I鈥檓 really ecstatic to come back to Huntsman Cancer Institute.鈥

Advice for Young Scientists

鈥淚 always encourage people to just ask for what you鈥檙e looking for and go try it out. If you don鈥檛 see the opportunity, that doesn鈥檛 mean it doesn鈥檛 exist. Oftentimes if you just email people and express your interest and tell them why, that opportunity becomes available to you. And I think that鈥檚 been absolutely true at every step of my career.鈥

What She Would Tell Patients

鈥淲e as scientists do feel the sense of urgency, and we always want things to move faster. But I think there is a really powerful perspective to have to look back at different periods of time and see how much progress we really have made. It is making a difference. Even if on any given day you don鈥檛 make a huge breakthrough, it happens over time. The cumulative effect of research is what really makes the difference.鈥

Cancer touches all of us.